Diploids in the Cryptococcus neoformans Serotype A Population Homozygous for the α Mating Type Originate via Unisexual Mating
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منابع مشابه
Diploids in the Cryptococcus neoformans Serotype A Population Homozygous for the α Mating Type Originate via Unisexual Mating
The ubiquitous environmental human pathogen Cryptococcus neoformans is traditionally considered a haploid fungus with a bipolar mating system. In nature, the alpha mating type is overwhelmingly predominant over a. How genetic diversity is generated and maintained by this heterothallic fungus in a largely unisexual alpha population is unclear. Recently it was discovered that C. neoformans can un...
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Isolates of Cryptococcus neoformans from Infected Animals Reveal Genetic Exchange in Unisexual, Mating Type Populations † Tien Bui, Xiaorong Lin,‡ Richard Malik, Joseph Heitman, and Dee Carter* Discipline of Microbiology, School of Molecular and Microbial Biosciences, University of Sydney, Sydney, New South Wales 2006, Australia; Post Graduate Foundation of Veterinary Science and Faculty of Vet...
متن کاملIsolates of Cryptococcus neoformans from infected animals reveal genetic exchange in unisexual, alpha mating type populations.
Sexual reproduction and genetic exchange are important for the evolution of fungal pathogens and for producing potentially infective spores. Studies to determine whether sex occurs in the pathogenic yeast Cryptococcus neoformans var. grubii have produced enigmatic results, however: basidiospores are the most likely infective propagules, and clinical isolates are fertile and genetically diverse,...
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Hybridization with polyploidization is a significant biological force driving evolution. The effect of combining two distinct genomes in one organism on the virulence potential of pathogenic fungi is not clear. Cryptococcus neoformans, the most common cause of fungal infection of the central nervous system, has a bipolar mating system with a and alpha mating types and occurs as A (haploid), D (...
متن کاملSerotype, mating type and ploidy of Cryptococcus neoformans strains isolated from patients in Brazil.
Serotype, mating type and ploidy of 84 strains of Cryptococcus neoformans isolated from 61 AIDS and 23 non-AIDS patients admitted in a tertiary teaching hospital in São Paulo, Brazil were examined. Among 61 strains isolated from AIDS patients, 60 strains were var. grubii (serotype A). Only one strain was var. gattii (serotype B). No var. neoformans (serotype D) was found. Among 23 strains isola...
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ژورنال
عنوان ژورنال: PLoS Pathogens
سال: 2009
ISSN: 1553-7374
DOI: 10.1371/journal.ppat.1000283